Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyeong Jun | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Rehman, Shaheed Ur | - |
dc.contributor.author | Ha, Sang Keun | - |
dc.contributor.author | Nakamura, Katsunori | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-06-22T14:21:31Z | - |
dc.date.available | 2021-06-22T14:21:31Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/9984 | - |
dc.description.abstract | Paradols are unsaturated ketones produced by biotransformation of shogaols in gingers. Among them, 6-paradol has been investigated as a new drug candidate due to its anti-inflammatory, apoptotic, and neuroprotective activities. In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes. 6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP2C19 isozymes, with IC50, values ranging from 3.8 to 21.4 mu M in recombinant CYP isozymes. However, the inhibition was not potentiated following pre-incubation, indicating that 6-paradol is not a mechanism-based inhibitor. These results suggest that pharmacokinetic drug-drug interactions might occur with 6-paradol, which must be considered in the process of new drug development. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1016/j.bmcl.2017.02.047 | - |
dc.identifier.scopusid | 2-s2.0-85014362090 | - |
dc.identifier.wosid | 000399262600036 | - |
dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry Letters, v.27, no.8, pp.1826 - 1830 | - |
dc.relation.isPartOf | Bioorganic and Medicinal Chemistry Letters | - |
dc.citation.title | Bioorganic and Medicinal Chemistry Letters | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1826 | - |
dc.citation.endPage | 1830 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordAuthor | 6-Paradol | - |
dc.subject.keywordAuthor | Unsaturated ketone | - |
dc.subject.keywordAuthor | Ginger | - |
dc.subject.keywordAuthor | CYP inhibition | - |
dc.subject.keywordAuthor | Drug-drug interaction | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X17301798?via%3Dihub | - |
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