Salinazinones A and B: Pyrrolidinyl-Oxazinones from Solar Saltern-Derived Streptomyces sp KMF-004
- Authors
- Kim, Min Cheol; Lee, Jung Hwan; Shin, Bora; Subedi, Lalita; Cha, Jin Wook; Park, Jin-Soo; Oh, Dong-Chan; Kim, Sun Yeou; Kwon, Hak Cheol
- Issue Date
- 16-Oct-2015
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.17, no.20, pp.5024 - 5027
- Journal Title
- ORGANIC LETTERS
- Volume
- 17
- Number
- 20
- Start Page
- 5024
- End Page
- 5027
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10030
- DOI
- 10.1021/acs.orglett.5b02495
- ISSN
- 1523-7060
- Abstract
- Salinazinones A (1) and B (2), two unprecedented pyrrolidinyl-oxazinones, were isolated from the culture broth of Streptomyces sp. KMF-004 from a solar saltern at Aphae Island, Korea. The structures of these salinazinones, which are unusual and consist of 2-methylpropenyl-1,3-oxazin-6-one bearing 1-oxopyrrolidinyl substituents, were assigned by spectral and chemical analyses using Mosher's method, circular dichroism (CD), and calculated ECD. Salinazinones are the first examples of a natural alkaloid class composed of an oxazinone-pyrrolidone conjugate.
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