Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy
DC Field | Value | Language |
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dc.contributor.author | Kang, Mino | - |
dc.contributor.author | Min, Kyunghoon | - |
dc.contributor.author | Jang, Joonyoung | - |
dc.contributor.author | Kim, Seung Chan | - |
dc.contributor.author | Kang, Myung Seo | - |
dc.contributor.author | Jang, Su Jin | - |
dc.contributor.author | Lee, Ji Young | - |
dc.contributor.author | Kim, Sang Heum | - |
dc.contributor.author | Kim, Moon Kyu | - |
dc.contributor.author | An, SeongSoo A. | - |
dc.contributor.author | Kim, MinYoung | - |
dc.date.available | 2020-02-28T07:44:57Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-10-01 | - |
dc.identifier.issn | 1547-3287 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10045 | - |
dc.description.abstract | This study evaluated the efficacy of umbilical cord blood (UCB) cell for patients with cerebral palsy (CP) in a randomized, placebo-controlled, double-blind trial and also assessed factors and mechanisms related to the efficacy. Thirty-six children (ages 6 months to 20 years old) with CP were enrolled and treated with UCB or a placebo. Muscle strength and gross motor function were evaluated at baseline and 1, 3, and 6 months after treatment. Along with function measurements, each subject underwent F-18-fluorodeoxyglucose positron emission tomography at baseline and 2 weeks after treatment. Cytokine and receptor levels were quantitated in serial blood samples. The UCB group showed greater improvements in muscle strength than the controls at 1 (0.94 vs. -0.35, respectively) and 3 months (2.71 vs. 0.65) after treatment (Ps<0.05). The UCB group also showed greater improvements in gross motor performance than the control group at 6 months (8.54 vs. 2.60) after treatment (P<0.01). Additionally, positron emission tomography scans revealed decreased periventricular inflammation in patients administered UCB, compared with those treated with a placebo. Correlating with enhanced gross motor function, elevations in plasma pentraxin 3 and interleukin-8 levels were observed for up to 12 days after treatment in the UCB group. Meanwhile, increases in blood cells expressing Toll-like receptor 4 were noted at 1 day after treatment in the UCB group, and they were correlated with increased muscle strength at 3 months post-treatment. In this trial, treatment with UCB alone improved motor outcomes and induced systemic immune reactions and anti-inflammatory changes in the brain. Generally, motor outcomes were positively correlated with the number of UCB cells administered: a higher number of cells resulted in better outcomes. Nevertheless, future trials are needed to confirm the long-term efficacy of UCB therapy, as the follow-up duration of the present trial was short. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.relation.isPartOf | STEM CELLS AND DEVELOPMENT | - |
dc.subject | LONG PENTRAXIN PTX3 | - |
dc.subject | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject | TRAUMATIC BRAIN-INJURY | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | MONONUCLEAR-CELLS | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | INFLAMMATION | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | RATS | - |
dc.subject | MECHANISMS | - |
dc.title | Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000361395900004 | - |
dc.identifier.doi | 10.1089/scd.2015.0074 | - |
dc.identifier.bibliographicCitation | STEM CELLS AND DEVELOPMENT, v.24, no.19, pp.2259 - 2268 | - |
dc.identifier.scopusid | 2-s2.0-84941912985 | - |
dc.citation.endPage | 2268 | - |
dc.citation.startPage | 2259 | - |
dc.citation.title | STEM CELLS AND DEVELOPMENT | - |
dc.citation.volume | 24 | - |
dc.citation.number | 19 | - |
dc.contributor.affiliatedAuthor | Kang, Mino | - |
dc.contributor.affiliatedAuthor | Kim, Seung Chan | - |
dc.contributor.affiliatedAuthor | An, SeongSoo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LONG PENTRAXIN PTX3 | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | TRAUMATIC BRAIN-INJURY | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | MONONUCLEAR-CELLS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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