Facile synthesis of boronic acid-functionalized magnetic nanoparticles for efficient dopamine extraction
- Authors
- Kook, Jeong Keun; Viet-Duc Phung; Koh, Do-Yeong; Lee, Sang-Wha
- Issue Date
- 2-Sep-2019
- Publisher
- SPRINGEROPEN
- Keywords
- Dopamine; Boronic acid; Core-shell; Dopamine; Polydopamine; Fluorescent intensity
- Citation
- NANO CONVERGENCE, v.6, no.1
- Journal Title
- NANO CONVERGENCE
- Volume
- 6
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1006
- DOI
- 10.1186/s40580-019-0200-7
- ISSN
- 2196-5404
- Abstract
- Because dopamine (DA) is one of the most critical neurotransmitters that influence a wide variety of motivated human behaviors, it is necessary to develop a facile diagnostic tool that can quantify the physiological level. In this study, core-shell magnetic silica nanoparticles (Fe3O4@SiO2) were prepared using a modified sol-gel reaction. The Fe3O4@SiO2 were functionalized using 3-aminophenylboronic acid (APBA) via a facile and rapid synthetic route, hereafter referred to as Fe3O4@SiO2@APBA The resultant Fe3O4@SiO2@APBA not only adsorbed DA molecules, but also were easily separated from solution using a simple magnetic manipulation. The adsorbed amounts of DA by the Fe3O4@SiO2@APBA were quantified by measuring the changes in fluorescence intensity of polydopamine (at 463 nm) originated from the self-polymerized DA remained in the supernatant before and after the adsorption process. The Fe3O4@SiO2@APBA exhibited two-stage adsorption behavior for DA, and the maximal adsorption capacity was 108.46 mu g/g at pH 8.5. Our particle system demonstrated the potential application for extracting compounds with cis-diols (including catechol amines) from the biological fluid.
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