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Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report

Authors
Woo, Hyun SunLee, Kyoung HwaYoon, Phill HoonKim, Su JiPark, InkeunKim, Young SaingAhn, Hee KyungHong, JunshikShin, Dong BokSym, Sun Jin
Issue Date
Oct-2015
Publisher
KOREAN CANCER ASSOCIATION
Keywords
Oxaliplatin; Colorectal neoplasms; Thrombocytopenia; Neutropenia
Citation
CANCER RESEARCH AND TREATMENT, v.47, no.4, pp.949 - 953
Journal Title
CANCER RESEARCH AND TREATMENT
Volume
47
Number
4
Start Page
949
End Page
953
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10101
DOI
10.4143/crt.2014.052
ISSN
1598-2998
Abstract
Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.
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