Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report
- Authors
- Woo, Hyun Sun; Lee, Kyoung Hwa; Yoon, Phill Hoon; Kim, Su Ji; Park, Inkeun; Kim, Young Saing; Ahn, Hee Kyung; Hong, Junshik; Shin, Dong Bok; Sym, Sun Jin
- Issue Date
- Oct-2015
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Oxaliplatin; Colorectal neoplasms; Thrombocytopenia; Neutropenia
- Citation
- CANCER RESEARCH AND TREATMENT, v.47, no.4, pp.949 - 953
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 47
- Number
- 4
- Start Page
- 949
- End Page
- 953
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10101
- DOI
- 10.4143/crt.2014.052
- ISSN
- 1598-2998
- Abstract
- Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.
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