Synthesis of Gold Nanoflowers Encapsulated with Poly(N-isopropylacrylamide-co-acrylic acid) Hydrogels
- Authors
- Bae, Saet-Byeol; Lee, Sang-Wha
- Issue Date
- Oct-2015
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Drug Delivery; Nanoparticle; Gold Nanoflowers; Hydrogel; NIPAM
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.15, no.10, pp.7962 - 7965
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 15
- Number
- 10
- Start Page
- 7962
- End Page
- 7965
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10110
- DOI
- 10.1166/jnn.2015.11232
- ISSN
- 1533-4880
- Abstract
- In this work, hydrogel-coated gold nanoflowers (AuNFs@hydrogel) were facilely prepared. First, gold nanoflowers (AuNFs) were synthesized by reducing gold acid with ascorbic acid in the presence of chitosan biopolymers, and the chitosan-mediated AuNFs were subsequently conjugated with oleic acid with carboxylate groups. Finally, the olefin-conjugated AuNFs were encapsulated with P(NIPAM-co-AAC) hydrogels via a radical polymerization reaction with co-monomer ratio of [NIPAM:AAc = 91:9 wt%]. The encapsulated hydrogels had a lower critical solution temperature (LCST) slightly above the physiological temperature and demonstrated a thermo-sensitive variation of particle size. The hydrogel-coated AuNFs can be utilized as a promising thermo-responsive drug delivery system with a unique optical property. As-prepared samples were characterized by DLS, SEM, TEM, UV-vis and Zeta potential meter.
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Collections - 공과대학 > 화공생명공학과 > 1. Journal Articles
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