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Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-kappa B signaling and protects intestinal epithelial barrier

Authors
Seong, Myeong A.Woo, Jong KyuKang, Ju-HeeJang, Yeong SuChoi, SeunghoJang, Young SaengLee, Taek HwanJung, Kyung HoonKang, Dong KyuHurh, Byung SeokKim, Dae EungKim, Sun YeouOh, Seung Hyun
Issue Date
31-Jul-2015
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Keywords
Colitis; Fermented wild ginseng; Inflammation; Macrophage; NF-kappa B
Citation
BMB REPORTS, v.48, no.7, pp.419 - 425
Journal Title
BMB REPORTS
Volume
48
Number
7
Start Page
419
End Page
425
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10320
DOI
10.5483/BMBRep.2015.48.7.039
ISSN
1976-6696
Abstract
Ginseng has been widely used for therapeutic and preventive purposes for thousands of years. However, orally administered ginseng has very low bioavailability and absorption in the intestine. Therefore, fermented ginseng was developed to enhance the beneficial effects of ginseng in the intestine. In this study, we investigated the molecular mechanisms underlying the anti-inflammatory activity of fermented wild ginseng (FWG). We found that FWG significantly alleviated the severity of colitis in a dextran sodium sulfate (DSS)-induced colitis mouse model, and decreased expression level of pro-inflammatory cytokines in colonic tissue. Moreover, we observed that FWG suppressed the infiltration of macrophages in DSS-induced colitis. FWG also attenuated the transcriptional activity of nuclear factor-kappa B (NF-kappa B) by reducing the translocation of NF-kappa B into the nucleus. Our data indicate that FWG contains anti-inflammatory activity via NF-kappa B inactivation and could be useful for treating colitis.
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