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A NEW N-GLUCOSYLATED INDOLE ALKALOID AND A NEW O-SERINE GLYCOSIDE FROM BERBERIS KOREANA
- Authors
- Kim, Ki Hyun; Kang, Hee Rae; Moon, Eunjung; Choi, Sang Un; Kang, Ki Sung; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- 1-Jul-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- HETEROCYCLES, v.91, no.7, pp.1429 - 1438
- Journal Title
- HETEROCYCLES
- Volume
- 91
- Number
- 7
- Start Page
- 1429
- End Page
- 1438
- ISSN
- 0385-5414
- Abstract
- A new N-glucosylated indole alkaloid, 1-(1-beta-glucopyranosyl)-3-(hydroxymethyl)-1H-indole (1) and a new O-serine glycoside, 3-O-alpha-Dxylopyranosyl-L-serine methyl ester (2), along with five known compounds (3-7) were isolated from the trunk of Berberis koreana. The structures of the new compounds were elucidated by 1D and 2D NMR data analysis and chemical reaction. Compounds 1, 2, 4, 5, and 7 reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line. In addition, compounds 4 and 5 showed moderate anti-proliferative activity against A549 and HCT-15 cell lines.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
- 한의과대학 > 한의예과 > 1. Journal Articles
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Related Researcher
- Kang, Ki Sung
- College of Korean Medicine (Premedical course of Oriental Medicine)