Detection of cholesterol molecules with a liquid crystal-based pH-driven sensor
DC Field | Value | Language |
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dc.contributor.author | Wei, Yibin | - |
dc.contributor.author | Jang, Chang-Hyun | - |
dc.date.available | 2020-02-28T08:45:59Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 0022-2461 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10349 | - |
dc.description.abstract | Determining cholesterol levels is of great importance in the detection of high risk for heart disease. Here, we developed a real-time sensing strategy for free cholesterol molecules, employing ultraviolet (UV)-treated liquid crystals (LCs). When 4-cyano-4'-pentylbiphenyl (5CB), a nematic LC material, is treated with UV light, it shows a bright-to-dark optical response to a very small change in pH from 7.0 to 7.1, which can be observed with a polarizing optical microscopy at the aqueous/LC interface. In diagnostic applications, the second most widely used enzymatic reaction between cholesterol and cholesterol oxidase is able to generate H+, which could be detected by pH-sensitive LCs. Exploiting these mechanisms, a cholesterol sensor was designed and the device performed well in a range of cholesterol concentrations from 10 to 300 mg/mL, which covers the physiologically relevant range of cholesterol in the human body (90-220 mg/mL). We also determined the limit of detection, 1 x 10(-9) mg/mL, and explored the effects of inhibitors on this sensor. The results obtained from this study may offer a simple tool for the detection of cholesterol compared with conventional methods and have potential for clinical diagnostics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS SCIENCE | - |
dc.subject | REAL-TIME | - |
dc.subject | BIOSENSOR | - |
dc.subject | INTERFACES | - |
dc.subject | AMPHIPHILES | - |
dc.subject | MEMBRANES | - |
dc.subject | OXIDE | - |
dc.subject | FILM | - |
dc.title | Detection of cholesterol molecules with a liquid crystal-based pH-driven sensor | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000354093500027 | - |
dc.identifier.doi | 10.1007/s10853-015-9027-8 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS SCIENCE, v.50, no.13, pp.4741 - 4748 | - |
dc.identifier.scopusid | 2-s2.0-84937761960 | - |
dc.citation.endPage | 4748 | - |
dc.citation.startPage | 4741 | - |
dc.citation.title | JOURNAL OF MATERIALS SCIENCE | - |
dc.citation.volume | 50 | - |
dc.citation.number | 13 | - |
dc.contributor.affiliatedAuthor | Wei, Yibin | - |
dc.contributor.affiliatedAuthor | Jang, Chang-Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REAL-TIME | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | INTERFACES | - |
dc.subject.keywordPlus | AMPHIPHILES | - |
dc.subject.keywordPlus | MEMBRANES | - |
dc.subject.keywordPlus | OXIDE | - |
dc.subject.keywordPlus | FILM | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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