Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations
- Authors
- Cho, Lisa Y.; Yang, Jae Jeong; Ko, Kwang-Pil; Ma, Seung Hyun; Shin, Aesun; Choi, Bo Youl; Kim, Hyun Ja; Han, Dong Soo; Song, Kyu Sang; Kim, Yong Sung; Chang, Soung-Hoon; Shin, Hai-Rim; Kang, Daehee; Yoo, Keun-Young; Park, Sue K.
- Issue Date
- Jul-2015
- Publisher
- SPRINGER
- Keywords
- Gastric cancer; Ornithine decarboxylase; SNPs; Phytoestrogen; Polyamine; NQO1; OAZ2; AMD1
- Citation
- GASTRIC CANCER, v.18, no.3, pp.495 - 503
- Journal Title
- GASTRIC CANCER
- Volume
- 18
- Number
- 3
- Start Page
- 495
- End Page
- 503
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10369
- DOI
- 10.1007/s10120-014-0396-5
- ISSN
- 1436-3291
- Abstract
- The study aimed to examine the association between genes encoding molecules in the ornithine decarboxylase (ODC)-polyamine pathway (ODC1, AMD1, NQO1, NOS2A, and OAZ2) and gastric cancer risk and whether the gene-phytoestrogen interaction modifies gastric cancer risk. Among 76 gastric cancer cases and their 1:4 matched controls within the Korean Multi-center Cancer Cohort, a total of 30 SNPs in five genes involved in the ODC pathway were primarily analyzed. The second-stage genotyping in 388 matched case-control sets was conducted to reevaluate the significant SNPs interacting with phytoestrogens during the primary analysis. The summary odds ratios (ORs) [95 % confidence intervals (CIs)] for gastric cancer were estimated. Interaction effects between the SNPs and plasma concentrations of phytoestrogens (genistein, daidzein, equol, and enterolactone) were evaluated. In the pooled analysis, NQO1 rs1800566 showed significant genetic effects on gastric cancer without heterogeneity [OR 0.83 (95 % CI 0.70-0.995)] and a greater decreased risk at high genistein/daidzein levels [OR 0.36 (95 % CI 0.15-0.90) and OR 0.26 (95 % CI 0.10-0.64), respectively; p (interaction) < 0.05]. Risk alleles of AMD1 rs1279599, AMD1 rs7768897, and OAZ2 rs7403751 had a significant gene-phytoestrogen (genistein and daidzein) interaction effect to modify the development of gastric cancer. They had an increased gastric cancer risk at low isoflavone levels, but a decreased risk at high isoflavone levels (p (interaction) < 0.01). Our findings suggest that common variants in the genes involved in the ODC pathway may contribute to the risk of gastric cancer possibly by modulating ODC polyamine biosynthesis or by interaction between isoflavones and NQO1, OAZ2, and AMD1.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10369)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.