Maximum standardized uptake value on positron emission tomography/computed tomography predicts clinical outcome in patients with relapsed or refractory diffuse large B-cell lymphoma
- Authors
- Jang, Hee Ryeong; Song, Moo Kon; Chung, Joo Seop; Yang, Deok Hwan; Lee, Jeong Ok; Hong, Junshik; Cho, Su Hee; Kim, Seong Jang; Shin, Dong Hoon; Park, Young Joo; Kang, Jin-Suk; Lee, Jeong Eun; Lee, Moon Won; Shin, Ho-Jin
- Issue Date
- Jun-2015
- Publisher
- KOREAN SOC HEMATOLOGY
- Keywords
- Positron emission tomography; SUVmax; aa-IPI
- Citation
- BLOOD RESEARCH, v.50, no.2, pp.97 - 102
- Journal Title
- BLOOD RESEARCH
- Volume
- 50
- Number
- 2
- Start Page
- 97
- End Page
- 102
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10469
- DOI
- 10.5045/br.2015.50.2.97
- ISSN
- 2287-979X
- Abstract
- Background Few clinical studies have clarified the prognostic factors that affect clinical outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after immunochemotherapy. Methods A total of 158 patients with relapsed or refractory DLBCL were enrolled. All patients underwent positron emission tomography/computed tomography (PET/CT) before and after salvage therapy. All enrolled patients previously received the ifosfamide, carboplatin, and etoposide regimen. Clinical outcomes were compared according to several factors (age >= 65 years, low age-adjusted International Prognostic Index [aa-IPI], maximum standardized uptake value [SUVmax] < 6.0 on PET/CT, time to relapse >= 12 months, complete response after salvage therapy). A low aa-IPI, SUVmax < 6.0, and time to relapse >= 12 months were independent prognostic factors for survival. Results In univariate analysis and multivariate analysis, SUVmax below 6.0 (P < 0.001 for progression-free survival (PFS), P < 0.001 for overall survival (OS)) and low aa-IPI (P < 0.001 for PFS, P < 0.001 for OS) were independent prognostic factors associated with favorable outcome. Conclusion The aa-IPI and initial SUVmax were powerful prognostic factors in patients with relapsed or refractory DLBCL.
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