De Novo Design and Synthesis of a -Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Lee, Junghun | - |
dc.contributor.author | Hah, Jung-Mi | - |
dc.date.available | 2020-02-28T09:42:24Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10482 | - |
dc.description.abstract | As a way to develop a neuroprotective agent for the JNK3-JIP1-binding site, peptidomimetics of JIP-1 as JNK3 allosteric regulators have been examined. The study consisted of in silico scaffold hopping, molecular docking, solution and solid-phase peptide syntheses, and K-d measurements using surface plasmon resonance. As a peptidomimetic of JIP1, heptamer mimetic 16 (K-d=2.72m) displayed a higher affinity than decamer JIP1 (K-d=23.6m). The high affinity of 16 implies that the characteristic -turn mimetic structure, phi-X-phi hydrophobic motif in 16, increased its affinity toward the JIP-site of JNK3. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.subject | JUN ACTIVATION DOMAIN | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | THERAPEUTIC TARGET | - |
dc.subject | HUMAN-DISEASES | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAY | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | IDENTIFICATION | - |
dc.subject | INHIBITOR | - |
dc.subject | BINDS | - |
dc.title | De Novo Design and Synthesis of a -Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000355339100010 | - |
dc.identifier.doi | 10.1002/asia.201403417 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-AN ASIAN JOURNAL, v.10, no.6, pp.1318 - 1326 | - |
dc.identifier.scopusid | 2-s2.0-84930207771 | - |
dc.citation.endPage | 1326 | - |
dc.citation.startPage | 1318 | - |
dc.citation.title | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Kim, Mi-hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | allosteric | - |
dc.subject.keywordAuthor | gamma turn | - |
dc.subject.keywordAuthor | JNK3 | - |
dc.subject.keywordAuthor | kinase inhibitors | - |
dc.subject.keywordAuthor | peptidomimetics | - |
dc.subject.keywordAuthor | scaffold hopping | - |
dc.subject.keywordPlus | JUN ACTIVATION DOMAIN | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | HUMAN-DISEASES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | BINDS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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