Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Sung Won | - |
dc.contributor.author | Lee, Heesu | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.date.available | 2020-02-28T09:43:20Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-05-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10540 | - |
dc.description.abstract | Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells. (C) 2015 Published by Elsevier Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | RENAL DAMAGE | - |
dc.subject | INJURY | - |
dc.subject | ANTICANCER | - |
dc.subject | NEPHROTOXICITY | - |
dc.subject | INVOLVEMENT | - |
dc.subject | DERIVATIVES | - |
dc.subject | PATHWAYS | - |
dc.subject | GINSENG | - |
dc.subject | STRESS | - |
dc.title | Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000353205000022 | - |
dc.identifier.doi | 10.1016/j.bmcl.2015.03.026 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.9, pp.1929 - 1932 | - |
dc.identifier.scopusid | 2-s2.0-84933497715 | - |
dc.citation.endPage | 1932 | - |
dc.citation.startPage | 1929 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chalcone | - |
dc.subject.keywordAuthor | Cisplatin-induced nephrotoxicity | - |
dc.subject.keywordAuthor | Renoprotection | - |
dc.subject.keywordAuthor | MAPKs-p53-caspase-3 | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | RENAL DAMAGE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | GINSENG | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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