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Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells
- Issue Date
- 1-May-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Chalcone; Cisplatin-induced nephrotoxicity; Renoprotection; MAPKs-p53-caspase-3
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.9, pp.1929 - 1932
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 25
- Number
- 9
- Start Page
- 1929
- End Page
- 1932
- ISSN
- 0960-894X
- Abstract
- Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells. (C) 2015 Published by Elsevier Ltd.
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Related Researcher
- Kang, Ki Sung
- College of Korean Medicine (Premedical course of Oriental Medicine)