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Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production
- Authors
- Jin, Qinghao; Lee, Chul; Lee, Jin Woo; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Kim, Jin Sook; Kim, Joo-Hwan; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- May-2015
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Paulownia coreana; Paulowniaceae; geranylated flavanone; nitric oxide inhibitor
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.63, no.5, pp.384 - 387
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 63
- Number
- 5
- Start Page
- 384
- End Page
- 387
- ISSN
- 0009-2363
- Abstract
- The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 mu m.
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Related Researcher
- Kim, Joo-Hwan
- BioNano Technology (Department of Life Sciences)