The Effect of Clonidine Pretreatment on Epidural Resiniferatoxin in a Neuropathic Pain Rat Model
- Authors
- Lee, Mi Geum; Lee, Dong Kyu; Huh, Billy K.; Choi, Sang Sik; Kim, Hee Zoo; Lim, Byung Gun; Kim, Hong Soon; Choi, Yun Suk; Hur, Won Seok; Lee, Mi Kyoung
- Issue Date
- Apr-2015
- Publisher
- OKAYAMA UNIV MED SCHOOL
- Keywords
- clonidine; epidural administration; resiniferatoxin; spinal nerve ligation rat model; thermal hyperalgesia
- Citation
- ACTA MEDICA OKAYAMA, v.69, no.2, pp.95 - 103
- Journal Title
- ACTA MEDICA OKAYAMA
- Volume
- 69
- Number
- 2
- Start Page
- 95
- End Page
- 103
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10640
- ISSN
- 0386-300X
- Abstract
- Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine which has been shown to relieve intradermal capsaicin-induced hyperalgesia-on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n = 6 each): RTX 500 ng, RTX tug, clonidine 20 mu g (Cl), Cl+RTX 500 ng, Cl+RTX mu g, or normal saline 20 mu L (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500 ng and RTX mu g groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl+RTX mu g rats' behavior scores indicated that they were more calm and comfortable compared to the RTX 1 mu g rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model.
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