YB-1 overexpression promotes a TGF-beta 1-induced epithelial-mesenchymal transition via Akt activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, Bin | - |
dc.contributor.author | Lee, Eun Byul | - |
dc.contributor.author | Cu, Jun | - |
dc.contributor.author | Kim, Yosup | - |
dc.contributor.author | Jang, Ho Hee | - |
dc.date.available | 2020-02-28T09:46:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10684 | - |
dc.description.abstract | The Y-box binding protein-1 (YB-1) is a transcription/translation regulatory protein, and the expression thereof is associated with cancer aggressiveness. In the present study, we explored the regulatory effects of YB-1 during the transforming growth factor-beta 1 (TGF-beta 1)-induced epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma cells. Downregulation of YB-1 increased E-cadherin promoter activity, and upregulation of YB-1 decreased promoter activity, suggesting that the YB-1 level may be correlated with the EMT. TGF-beta 1 induced YB-1 expression, and TGF-beta 1 translocated cytosolic YB-1 into the nucleus. YB-1 overexpression promoted TGF-beta 1-induced downregulation of epithelial markers, upregulation of mesenchymal markers, and cell migration. Moreover, YB-1 overexpression enhanced the expression of E-cadherin transcriptional repressors via TGF-beta 1-induced Akt activation. Our findings afford new insights into the role played by YB-1 in the TGF-beta 1 signaling pathway. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | BOX-BINDING-PROTEIN | - |
dc.subject | TRANSCRIPTION FACTOR YB-1 | - |
dc.subject | BREAST-CANCER | - |
dc.subject | TGF-BETA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | NUCLEAR EXPRESSION | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | E-CADHERIN | - |
dc.subject | PROGRESSION | - |
dc.subject | RESISTANCE | - |
dc.title | YB-1 overexpression promotes a TGF-beta 1-induced epithelial-mesenchymal transition via Akt activation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000351482200021 | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.01.114 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.458, no.2, pp.347 - 351 | - |
dc.identifier.scopusid | 2-s2.0-84923268973 | - |
dc.citation.endPage | 351 | - |
dc.citation.startPage | 347 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 458 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Ha, Bin | - |
dc.contributor.affiliatedAuthor | Lee, Eun Byul | - |
dc.contributor.affiliatedAuthor | Cu, Jun | - |
dc.contributor.affiliatedAuthor | Kim, Yosup | - |
dc.contributor.affiliatedAuthor | Jang, Ho Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | YB-1 | - |
dc.subject.keywordAuthor | TGF-beta 1 | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | E-cadherin | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordPlus | BOX-BINDING-PROTEIN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR YB-1 | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NUCLEAR EXPRESSION | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.