YB-1 overexpression promotes a TGF-beta 1-induced epithelial-mesenchymal transition via Akt activation
- Authors
- Ha, Bin; Lee, Eun Byul; Cu, Jun; Kim, Yosup; Jang, Ho Hee
- Issue Date
- 6-Mar-2015
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- YB-1; TGF-beta 1; Epithelial-mesenchymal transition; E-cadherin; Akt
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.458, no.2, pp.347 - 351
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 458
- Number
- 2
- Start Page
- 347
- End Page
- 351
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10684
- DOI
- 10.1016/j.bbrc.2015.01.114
- ISSN
- 0006-291X
- Abstract
- The Y-box binding protein-1 (YB-1) is a transcription/translation regulatory protein, and the expression thereof is associated with cancer aggressiveness. In the present study, we explored the regulatory effects of YB-1 during the transforming growth factor-beta 1 (TGF-beta 1)-induced epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma cells. Downregulation of YB-1 increased E-cadherin promoter activity, and upregulation of YB-1 decreased promoter activity, suggesting that the YB-1 level may be correlated with the EMT. TGF-beta 1 induced YB-1 expression, and TGF-beta 1 translocated cytosolic YB-1 into the nucleus. YB-1 overexpression promoted TGF-beta 1-induced downregulation of epithelial markers, upregulation of mesenchymal markers, and cell migration. Moreover, YB-1 overexpression enhanced the expression of E-cadherin transcriptional repressors via TGF-beta 1-induced Akt activation. Our findings afford new insights into the role played by YB-1 in the TGF-beta 1 signaling pathway. (C) 2015 Elsevier Inc. All rights reserved.
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