Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation
DC Field | Value | Language |
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dc.contributor.author | Cha, Seon-Heui | - |
dc.contributor.author | Hwang, Yongha | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-02-27T02:22:47Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1068 | - |
dc.description.abstract | Glucose degradation is aberrantly increased in hyperglycemia, which causes various harmful effects on the liver. Glyoxalase-1 (Glo-1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MGO), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs) and inflammation. Here, we investigated the anti-inflammatory effect of indole-4-carboxaldehyde (ST-I4C), which was isolated from the edible seaweed Sargassum thunbergii, on MGO-induced inflammation in HepG2 cells, a human hepatocyte cell line. ST-I4C attenuated the MGO-induced expression of inflammatory-related genes, such as tumor necrosis factor (TNF)-alpha and IFN-gamma by activating nuclear factor-kappa B (NF-kappa B) without toxicity in HepG2 cells. In addition, ST-I4C reduced the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Interestingly, both the mRNA and protein expression levels of Glo-1 increased following ST-I4C treatment, and the decrease in Glo-1 mRNA expression caused by MGO exposure was rescued by ST-I4C pretreatment. These results suggest that ST-I4C shows anti-inflammatory activity against MGO-induced inflammation in human hepatocytes by preventing an increase in the pro-inflammatory gene expression and AGE formation. Therefore, it represents a potential therapeutic agent for the prevention of hepatic steatosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.subject | FATTY LIVER-DISEASE | - |
dc.subject | END-PRODUCTS AGES | - |
dc.subject | GLYOXALASE-I | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | SERUM-LEVELS | - |
dc.subject | RECEPTOR | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | DERIVATIVES | - |
dc.subject | FRUCTOSE | - |
dc.subject | STRESS | - |
dc.title | Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000487959700010 | - |
dc.identifier.doi | 10.3390/md17090486 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.17, no.9 | - |
dc.identifier.scopusid | 2-s2.0-85071508466 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Hwang, Yongha | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hepatic steatosis | - |
dc.subject.keywordAuthor | metabolic disease | - |
dc.subject.keywordAuthor | AGEs | - |
dc.subject.keywordAuthor | seaweed | - |
dc.subject.keywordAuthor | Sargassum thunbergii | - |
dc.subject.keywordPlus | FATTY LIVER-DISEASE | - |
dc.subject.keywordPlus | END-PRODUCTS AGES | - |
dc.subject.keywordPlus | GLYOXALASE-I | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | FRUCTOSE | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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