Clinical Guidelines for the Diagnosis and Treatment of Cushing's Disease in Korea
- Authors
- Hur, Kyu Yeon; Kim, Jung Hee; Kim, Byung Joon; Kim, Min-Seon; Lee, Eun Jig; Kim, Sung-Woon
- Issue Date
- Mar-2015
- Publisher
- KOREAN ENDOCRINE SOC
- Keywords
- Adrenocorticotropic hormone; Corticotropin-releasing hormone; Pituitary ACTH hypersecretion; Cushing' s disease; Inferior petrosal sinus sampling; Pasireotide; Pituitary adenomas; Transsphenoidal approach
- Citation
- ENDOCRINOLOGY AND METABOLISM-ENM, v.30, no.1, pp.7 - 18
- Journal Title
- ENDOCRINOLOGY AND METABOLISM-ENM
- Volume
- 30
- Number
- 1
- Start Page
- 7
- End Page
- 18
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10733
- DOI
- 10.3803/EnM.2015.30.1.7
- ISSN
- 2093-596X
- Abstract
- Cushing's disease (CD) is a rare disorder characterized by the overproduction of adrenocorticotropic hormone due to a pituitary adenoma that ultimately stimulates excessive cortisol secretion from the adrenal glands. Prior to the detection of pituitary adenomas, various clinical signs of CD such as central obesity, moon face, hirsutism, and facial plethora are usually already present. Uncontrolled hypercortisolism is associated with metabolic, cardiovascular, and psychological disorders that result in increased mortality. Hence, the early detection and treatment of CD are not only important but mandatory. Because its clinical manifestations vary from patient to patient and are common in other obesity-related conditions, the precise diagnosis of CD can be problematic. Thus, the present set of guidelines was compiled by Korean experts in this field to assist clinicians with the screening, diagnoses, and treatment of patients with CD using currently available tests and treatment modalities.
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