Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids
DC Field | Value | Language |
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dc.contributor.author | Oh, Yoon Sin | - |
dc.date.available | 2020-02-28T10:41:37Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 2093-3665 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10749 | - |
dc.description.abstract | Pancreatic islets are responsible for blood glucose homeostasis. Reduced numbers of functional (insulin-secreting) beta-cells in pancreatic islets underlies diabetes. Restoration of the secretion of the proper amount of insulin is a goal. Beta-cell mass is increased by neogenesis, proliferation and cell hypertrophy, and is decreased by beta-cell death primarily through apoptosis. Many hormones and nutrients affect beta-cell mass, and glucose and free fatty acid are thought to be the most important determinants of beta-cell equilibrium. A number of molecular pathways have been implicated in beta-cell mass regulation and have been studied. This review will focus on the role of the principle metabolites, glucose and free fatty acid, and the downstream signaling pathways regulating beta-cell mass by these metabolites. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MEDRANG | - |
dc.relation.isPartOf | ANATOMY & CELL BIOLOGY | - |
dc.title | Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000448067600003 | - |
dc.identifier.doi | 10.5115/acb.2015.48.1.16 | - |
dc.identifier.bibliographicCitation | ANATOMY & CELL BIOLOGY, v.48, no.1, pp.16 - 24 | - |
dc.identifier.kciid | ART001972062 | - |
dc.identifier.scopusid | 2-s2.0-84946479230 | - |
dc.citation.endPage | 24 | - |
dc.citation.startPage | 16 | - |
dc.citation.title | ANATOMY & CELL BIOLOGY | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Oh, Yoon Sin | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Glucose | - |
dc.subject.keywordAuthor | Free fatty acids | - |
dc.subject.keywordAuthor | Beta-cell mass regulation | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.relation.journalResearchArea | Anatomy & Morphology | - |
dc.relation.journalWebOfScienceCategory | Anatomy & Morphology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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