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Protective Effect of 10-Hz, 1-mT Electromagnetic Field Exposure Against Hypoxia/Reoxygenation Injury in HK-2 Cells
- Authors
- Lim, Soonho; Kim, Soo-Chan; Kim, Jae Young
- Issue Date
- Mar-2015
- Publisher
- CHINESE CENTER DISEASE CONTROL & PREVENTION
- Citation
- BIOMEDICAL AND ENVIRONMENTAL SCIENCES, v.28, no.3, pp.231 - 234
- Journal Title
- BIOMEDICAL AND ENVIRONMENTAL SCIENCES
- Volume
- 28
- Number
- 3
- Start Page
- 231
- End Page
- 234
- ISSN
- 0895-3988
- Abstract
- We investigated the protective effects of electromagnetic field (EMF) on the survival of the human renal proximal tubular cell line, HK-2, using an in vitro hypoxia/reoxygenation (H/R) injury model. The survival rate of cells cultured under H/R condition declined significantly, while the intracellular reactive oxygen species (ROS) levels markedly increased. The 10 Hz/1 mT EMF exposure reversed the H/R induced reduction in cell survival and induction of intracellular ROS. Our results suggest that 10 Hz/1 mT EMF exposure could inhibit H/R-induced cell death of HK-2 via suppression of intracellular ROS production and that this treatment might be clinically useful for the amelioration of renal ischemia/reperfusion injury.
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Related Researcher
- Kim, Jae Young
- BioNano Technology (Department of Life Sciences)