Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells
- Authors
- Yun, Jieun; Kim, Bo Geun; Kang, Jong Soon; Park, Song-Kyu; Lee, Kiho; Hyun, Dong-Hoon; Kim, Hwan Mook; In, Man-Jin; Kim, Dong Chung
- Issue Date
- 1-Jan-2015
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- lung metastasis; cancer invasion; matrix metalloprotease-2; lipid-soluble ginseng extract
- Citation
- JOURNAL OF MEDICINAL FOOD, v.18, no.1, pp.102 - 108
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 18
- Number
- 1
- Start Page
- 102
- End Page
- 108
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10871
- DOI
- 10.1089/jmf.2013.3138
- ISSN
- 1096-620X
- Abstract
- This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 mu g/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000 mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.
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