Screening of herbal medicines from China with inhibitory activity on advanced glycation end products formation (XIII)중국 약용식물의 최종당화산물 생성저해활성 검색(XIII)
- Other Titles
- 중국 약용식물의 최종당화산물 생성저해활성 검색(XIII)
- Authors
- Choi, S.J.; Kim, Y.S.; Kim, J.H.; Hang, S.; Kim, J.S.
- Issue Date
- Sep-2015
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Advanced glycation end products (AGEs); Diabetic complications; Herbal medicines
- Citation
- Korean Journal of Pharmacognosy, v.46, no.3, pp.260 - 267
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 46
- Number
- 3
- Start Page
- 260
- End Page
- 267
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/10943
- ISSN
- 0253-3073
- Abstract
- Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 111 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 9 herbal medicines (IC50: <5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Barleria cristata (leaves), Calotropis gigantea (stems), Ardisia virens (leaves), Dalbergia yunnanensis (leaves) Pittosporum runcatum (leaves), Ardisia japonica (leaves), Rhododendron racemosum (twigs), Oxyria sinensiss (aerial parts), Pyrrosia calvata (whole plants), showed more potent inhibitory activity (approximately 15-40 fold) than the positive control aminoguanidine (IC50: 76.47 μg/ml). © 2015, Korean Society of Pharmacognosy. All rights reserved.
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