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Screening of herbal medicines from korea with inhibitory activity on advanced glycation end products formation (XII)한국 약용식물의 최종당화산물 생성저해활성 검색 (XII)
- Other Titles
- 한국 약용식물의 최종당화산물 생성저해활성 검색 (XII)
- Authors
- Choi, S.J.; Kim, Y.S.; Kim, J.H.; Kim, J.S.
- Issue Date
- Sep-2015
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Advanced glycation end products (AGEs); Diabetic complications; Herbal medicines
- Citation
- Korean Journal of Pharmacognosy, v.46, no.3, pp.250 - 259
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 46
- Number
- 3
- Start Page
- 250
- End Page
- 259
- ISSN
- 0253-3073
- Abstract
- Advanced glycation end products (AGEs) have been implicated in diabetic complications. In this study, the inhibitory effect on AGEs formation of 156 Korean herbal medicines has been evaluated. Among them, 15 Korean herbal medicines were showed to have significant effect (IC50: <10 μg/ml) compared to positive reference, aminoguandine (IC50: 76.47±4.81 μg/ ml). Especially, four herbal medicines, Alnus firma (leaves, IC50: 3.25±0.10 μg/ml), Juncus decipiens (whole plants, IC50: 4.30±0.44 μg/ml), Smilax china (stems, IC50: 3.55±0.21 μg/ml), and Vicia amoena (Aerial parts, IC50: 4.25±0.06 μg/ml) showed more potent inhibitory activity approximately 8-24 fold) than the positive control aminoguanidine. © 2015, Korean Society of Pharmacognosy. All rights reserved.
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Related Researcher
- Kim, Joo-Hwan
- BioNano Technology (Department of Life Sciences)