茯神의 인지기능 향상 및 해마 신경세포분화 촉진에 대한 효능 연구Effect of Hoelen Cum Radix on learning and memory enhancement via stimulation of neuronal differentiation in the hippocampus of the mouse brain
- Other Titles
- Effect of Hoelen Cum Radix on learning and memory enhancement via stimulation of neuronal differentiation in the hippocampus of the mouse brain
- Authors
- 최진규; 심여문; 김원남; 김선여; 오명숙
- Issue Date
- Mar-2015
- Publisher
- 대한본초학회
- Keywords
- Hoelen Cum Radix; memory and cognitive function; neuronal differentiation; neurite outgrowth
- Citation
- 대한본초학회지, v.30, no.2, pp.43 - 48
- Journal Title
- 대한본초학회지
- Volume
- 30
- Number
- 2
- Start Page
- 43
- End Page
- 48
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11686
- ISSN
- 1229-1765
- Abstract
- Objectives : The aim of this study was to investigate the memory enhancing properties of extract of Hoelen Cum Radix (HCR) and its possible mechanism in mice of normal condition.
Methods : We evaluated the effects of HCR on cognitive function and memory enhancement in normal mice. Male ICR mice were orally administrated with HCR 100 mg/kg for 7 days and equal volume of saline was administrated to the control group in the same condition. We conducted two behavioral tests which measure the spatial working memory (Y-maze test) and cognitive fear memory (passive avoidance test). We also investigated whether HCR affects the hippocampal neurogenesis in the brain. To assess the effects of HCR on neural progenitor cell differentiation and neurite outgrowth in the early stage of hippocampal neurogenesis, we performed doublecortin (DCX), a direct neurogenesis marker, immunohistochemical analysis in the dentate gyrus (DG) of the mouse hippocampus.
Results : HCR significantly enhanced memory and cognitive function as determined by the Y-maze test (p<0.05) and passive avoidance test (p<0.001). Moreover, HCR increased DCX positive cells (p<0.01) and neurite length (p<0.01) compared to the control group. These results indicated that HCR stimulates differentiation of neural progenitor cells and promotes neurite outgrowth in hippocampal DG of the mice.
Conclusion : We concluded that HCR shows memory enhancing effects through the stimulation of hippocampal neurogenesis as a consequence of accelerated neuronal differentiation and neurite outgrowth in the DG of the hippocampus after HCR treatment.
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