加味紫雲膏가 mouse의 피부화상 치료에 대한 분자생물학적 효과 및 기전연구

Abstract

Objective: The aim of this study was to investigate the wound healing effect of herbal ointment, Gamijaungo,on the burn-induced model. Reports about Gamijaungo on the wound healing effect by local application in micemodel or human study have published in the several domestic or internationally, but most are anecdotal and lacksolid scientific evidence. Method: We observed the morphologic and histologic changes in the burn-induced mice model. we countedwhite blood cell and platelet changes. we confirmed VEGF, PI3K and pAkt protein expression by Western blotanalysis. Result: In this study, we observed that Gamijaungo showed strong wound healing effects in the morphologicand histologic changes in the burn-induced mice model. Also we found that the significant changes of white bloodcell and platelet changes by the treatment of Gamijaungo. In molecular mechanism, we got the strong positiveeffect by Gamijaungo treatment on angiogenesis, a key process in the formation of the granulation tissue duringwound healing. Conclusion: These findings suggest the potential use of Gamijaungo as a therapeutic in thermal burn-inducedskin injuries.