Effect of Antioxidant and Antifungal Activity of Deacetylated Hyaluronic Acid

Abstract

HA is unbranched linear polysaccharide chain which has a high molecular weight composed of D-glucuronic acid (GlcUA) and N-acetyl-D-glucosamine (GlcNAc). It was distributed broadly throughout connective tissue, joints, epitherial in human and mammals. In this study, deacetylated hyaluronic acid (DA-HA) and high molecular weight hyaluronic acid (HMWHA) were studied to examine the antioxidant activity and antifungal effect. DA-HA indicated significant antioxidant relative activity of ferric ion reducing antioxidant power (FRAP) and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) di-ammonium salt (ABTS) radical cation scavenging, respectively. In particular, DA-HA showed higher antioxidant activity than HMWHA. Also, It has significant antifungal effect on P. italicum known as fungi of clementine peel. These results demonstrated that DA-HA could be considered as a material of functional cosmetics owing to superior antioxidant activity and applied to agricultural industry as a fungi static agent.