Effect of Antioxidant and Antifungal Activity of Deacetylated Hyaluronic Acid
- Authors
- 이춘근; 박제권
- Issue Date
- 2015
- Publisher
- 한국키틴키토산학회
- Keywords
- Hyaluronic acid; Deacetylation; Antioxidant activity; Antifungal effect; Chitosan
- Citation
- Journal of Chitin and Chitosan, v.20, no.3, pp.175 - 181
- Journal Title
- Journal of Chitin and Chitosan
- Volume
- 20
- Number
- 3
- Start Page
- 175
- End Page
- 181
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11830
- DOI
- 10.17642/jcc.20.3.4
- ISSN
- 1229-4160
- Abstract
- HA is unbranched linear polysaccharide chain which has a high molecular weight composed of D-glucuronic acid (GlcUA) and N-acetyl-D-glucosamine (GlcNAc). It was distributed broadly throughout connective tissue, joints, epitherial in human and mammals. In this study, deacetylated hyaluronic acid (DA-HA) and high molecular weight hyaluronic acid (HMWHA) were studied to examine the antioxidant activity and antifungal effect. DA-HA indicated significant antioxidant relative activity of ferric ion reducing antioxidant power (FRAP) and 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) di-ammonium salt (ABTS) radical cation scavenging, respectively. In particular, DA-HA showed higher antioxidant activity than HMWHA. Also, It has significant antifungal effect on P. italicum known as fungi of clementine peel. These results demonstrated that DA-HA could be considered as a material of functional cosmetics owing to superior antioxidant activity and applied to agricultural industry as a fungi static agent.
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