Role of apolipoprotein E in neurodegenerative diseases
- Authors
- Van Giau, Vo; Bagyinszky, Eva; An, Seong Soo A.; Kim, SangYun
- Issue Date
- 2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- apolipoprotein E; pathogenesis; diseases
- Citation
- NEUROPSYCHIATRIC DISEASE AND TREATMENT, v.11, pp.1723 - 1737
- Journal Title
- NEUROPSYCHIATRIC DISEASE AND TREATMENT
- Volume
- 11
- Start Page
- 1723
- End Page
- 1737
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11844
- DOI
- 10.2147/NDT.S84266
- ISSN
- 1178-2021
- Abstract
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. APOE-dependent alterations of the endocytic pathway can affect different functions. APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-beta peptide, regulating amyloid-beta aggregations and clearances in the brain. Several APOE isoforms with major structural differences were discovered and shown to influence the brain lipid transport, glucose metabolism, neuronal signaling, neuroinflammation, and mitochondrial function. This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
- 산업·환경대학원 > 산업환경공학과 > 1. Journal Articles
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