Improvement in Tracing Quantum Dot-Conjugated Nanospheres for In Vivo Imaging by Eliminating Food Autofluorescence
- Authors
- Park, Chul-Kyu; Cho, Hoonsung
- Issue Date
- 2015
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Citation
- JOURNAL OF NANOMATERIALS
- Journal Title
- JOURNAL OF NANOMATERIALS
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11854
- DOI
- 10.1155/2015/894353
- ISSN
- 1687-4110
- Abstract
- Fluorescence imaging using fluorescent probes has demonstrated long-term stability and brightness suitable for in vivo deep-tissue imaging, but it also allows intense background fluorescence associated with food in the near-infrared (IR) range. We investigated effects of changing rodent diet on food autofluorescence, in the presence of quantum dots-conjugated magnetic nanospheres (QD-MNSs). Replacement of a regular rodent diet with a purified diet has great improvement in removing autofluorescence in the near-infrared range ideal for in vivo fluorescence imaging. By feeding a purified diet for eliminating ingredients impairing desirable fluorescence signals in the near-IR range, food autofluorescence was clearly eliminated and fluorescence probes, QD-MNSs, introduced by i.v. injection were effectively traced in a mouse by a distinctive signal-to-noise ratio.
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