Cytotoxicity and Biological Efficacy of Exendin-4-Encapsulated Solid Lipid Nanoparticles in INS-1 Cells
DC Field | Value | Language |
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dc.contributor.author | Jun, Hee-Sook | - |
dc.contributor.author | Bae, Gongdeuk | - |
dc.contributor.author | Ko, Young Tag | - |
dc.contributor.author | Oh, Yoon Sin | - |
dc.date.available | 2020-02-28T14:44:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 1687-4110 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11857 | - |
dc.description.abstract | Exendin-4 (Ex-4), a peptide of glucagon-like peptide-1 receptor agonist, is a potent insulinotropic agent and alternative drug delivery systems to increase therapeutic utility have been explored. We developed exendin-4-encapsulated solid lipid nanoparticles (Eudragit Ex-4 SLNs) and compared the effects of Eudragit Ex-4 SLNs with those of native Ex-4 on INS-1 cells. We observed no significant toxic effects of nanoparticles at concentrations from 1 nM to 100 nM. Similar to Ex-4, Eudragit Ex-4 SLNs stimulated the production of cyclic AMP at 10 nM. Moreover, unlike treatment with the vehicle, treatment with 10 nM Eudragit Ex-4 SLNs increased insulin mRNA levels and insulin secretion. These insulinotropic effects of Eudragit Ex-4 SLNs were comparable to those of Ex-4. Thus, our in vitro results suggest that the biological effects of Eudragit Ex-4 SLNs are similar to those of Ex-4, and further in vivo pharmacokinetic studies are required to propose an alternative sustained release drug system. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | JOURNAL OF NANOMATERIALS | - |
dc.title | Cytotoxicity and Biological Efficacy of Exendin-4-Encapsulated Solid Lipid Nanoparticles in INS-1 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000361240800001 | - |
dc.identifier.doi | 10.1155/2015/753569 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOMATERIALS, v.2015 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84941687147 | - |
dc.citation.title | JOURNAL OF NANOMATERIALS | - |
dc.citation.volume | 2015 | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.contributor.affiliatedAuthor | Bae, Gongdeuk | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.contributor.affiliatedAuthor | Oh, Yoon Sin | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GLUCAGON-LIKE PEPTIDE-1 | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BETA-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SYNTHETIC EXENDIN-4 | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | EXENATIDE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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