Recanalization Rate and Clinical Outcome in Acute Carotid-T Occlusion
- Authors
- Noh, Young; Jung, Cheol Kyu; Hong, Jeong-Ho; Jeong, Jin-Heon; Chang, Jun Young; Kim, Beom Joon; Bae, Hee-Joon; Kwon, O-Ki; Oh, Chang Wan; Han, Moon-Ku
- Issue Date
- Sep-2015
- Publisher
- KARGER
- Keywords
- Thrombolysis; Recanalization; Carotid-T occlusion; Acute stroke treatment; Cerebral infarction; Outcome
- Citation
- EUROPEAN NEUROLOGY, v.74, no.1-2, pp.36 - 42
- Journal Title
- EUROPEAN NEUROLOGY
- Volume
- 74
- Number
- 1-2
- Start Page
- 36
- End Page
- 42
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11878
- DOI
- 10.1159/000434628
- ISSN
- 0014-3022
- Abstract
- Background: Acute carotid-T occlusion results in both low recanalization rates and poor outcomes. We investigated clinical outcomes and recanalization in a rare case of thrombolytic therapy. Methods: A consecutive series of patients with acute carotid-T occlusion who were treated with either bridging intravenous (IV) plus intra-arterial (IA) thrombolysis or IA alone were analyzed. Complete recanalization was defined as a thrombolysis in cerebral infarction (TICI) grade of 3. A favorable outcome was defined as a modified Rankin Scale (mRS) score of <= 2. Results: Of the 40 patients, 6 (15%) had favorable outcomes, and 34 (85%) had poor outcomes. Favorable outcomes were significantly associated with a lower National Institutes of Health Stroke Scale (NIHSS) score after revascularization treatment and higher rates of complete recanalization (p < 0.01, p < 0.024, respectively). Complete recanalization was achieved in all patients with favorable clinical outcomes and 5 (83%) patients had received combined IV/IA thrombolysis (p = 0.381). Conclusions: The results suggest that complete recanalization for acute carotid-T occlusion improves clinical outcomes. In that regard, bridging IV/IA thrombolysis may be more efficacious than IA alone. (C) 2015 S. Karger AG, Basel
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