Effects of carbon nanofiber on physiology of Drosophila
DC Field | Value | Language |
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dc.contributor.author | Lee, Shin-Hae | - |
dc.contributor.author | Lee, Hye-Yeon | - |
dc.contributor.author | Lee, Eun-Ji | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.contributor.author | Min, Kyung-Jin | - |
dc.date.available | 2020-02-28T14:45:42Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11915 | - |
dc.description.abstract | As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 mu g/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 mu g/mL) reduced larval viability based on the pupa: egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 mu g/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 mu g/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | DIFFERENTIAL TOXICITY | - |
dc.subject | CALORIC RESTRICTION | - |
dc.subject | LIFE-SPAN | - |
dc.subject | IN-VITRO | - |
dc.subject | NANOTUBES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MELANOGASTER | - |
dc.subject | APOPTOSIS | - |
dc.subject | SILVER | - |
dc.title | Effects of carbon nanofiber on physiology of Drosophila | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000354857300001 | - |
dc.identifier.doi | 10.2147/IJN.S82637 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.3687 - 3697 | - |
dc.identifier.scopusid | 2-s2.0-84930505213 | - |
dc.citation.endPage | 3697 | - |
dc.citation.startPage | 3687 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | toxicity | - |
dc.subject.keywordAuthor | Drosophila melanogaster | - |
dc.subject.keywordAuthor | lifespan | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DIFFERENTIAL TOXICITY | - |
dc.subject.keywordPlus | CALORIC RESTRICTION | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | NANOTUBES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SILVER | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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