Effects of carbon nanofiber on physiology of Drosophila
- Authors
- Lee, Shin-Hae; Lee, Hye-Yeon; Lee, Eun-Ji; Khang, Dongwoo; Min, Kyung-Jin
- Issue Date
- 2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- toxicity; Drosophila melanogaster; lifespan; reactive oxygen species
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.3687 - 3697
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 10
- Start Page
- 3687
- End Page
- 3697
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11915
- DOI
- 10.2147/IJN.S82637
- ISSN
- 1178-2013
- Abstract
- As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 mu g/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 mu g/mL) reduced larval viability based on the pupa: egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 mu g/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 mu g/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.
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