Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
- Authors
- Ankireddy, Seshadri Reddy; Kim, Jongsung
- Issue Date
- Aug-2015
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- InP/ZnS QDs; Parkinson' s disease; L-dopamine; ascorbic acid; neurotransmitter; photoluminescence
- Citation
- INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.113 - 119
- Journal Title
- INTERNATIONAL JOURNAL OF NANOMEDICINE
- Volume
- 10
- Start Page
- 113
- End Page
- 119
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11976
- DOI
- 10.2147/IJN.S88388
- ISSN
- 1178-2013
- Abstract
- Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson's disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to deficiency of dopamine. Several studies have been performed to detect dopamine by using electrochemical analysis. In this study, quantum dots (QDs) were used as sensing media for the detection of dopamine. The surface of the QDs was modified with L-cysteine by coupling reaction to increase the selectivity of dopamine. The fluorescence of cysteine-capped indium phosphide/zinc sulfide QDs was quenched by dopamine with various concentrations in the presence of ascorbic acid. This method shows good selectivity for dopamine detection, and the detection limit was 5 nM.
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Collections - 공과대학 > 화공생명공학과 > 1. Journal Articles
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