Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery
DC Field | Value | Language |
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dc.contributor.author | Joo, Jae Yeon | - |
dc.contributor.author | Park, Gilyong | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.date.available | 2020-02-28T15:42:08Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11977 | - |
dc.description.abstract | In the development of effective drug delivery carriers, many researchers have focused on the usage of nontoxic and biocompatible materials and surface modification with targeting molecules for tumor-specific drug delivery. Fibrinogen (Fbg), an abundant glycoprotein in plasma, could be a potential candidate for developing drug carriers because of its biocompatibility and tumor-targeting property via arginine-glycine-aspartate (RGD) peptide sequences. Doxorubicin (DOX), a chemotherapeutic agent, was covalently conjugated to Fbg, and the microspheres were prepared. Acid-labile and non-cleavable linkers were used for the conjugation of DOX to Fbg, resulting in an acid-triggered drug release under a mild acidic condition and a slow-controlled drug release, respectively. In vitro cytotoxicity tests confirmed low cytotoxicity in normal cells and high antitumor effect toward cancer cells. In addition, it was discovered that a longer linker could make the binding of cells to Fbg drug carriers easier. Therefore, DOX-linker-Fbg microspheres could be a suitable drug carrier for safer and effective drug delivery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | PEPTIDE-BOND | - |
dc.subject | PLATELET | - |
dc.subject | ALPHA(V)BETA(3) | - |
dc.subject | NANOPARTICLES | - |
dc.subject | HYDROLYSIS | - |
dc.subject | EXPRESSION | - |
dc.subject | CONJUGATE | - |
dc.subject | MICELLES | - |
dc.title | Biocompatible and biodegradable fibrinogen microspheres for tumor-targeted doxorubicin delivery | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365122300011 | - |
dc.identifier.doi | 10.2147/IJN.S88381 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.101 - 111 | - |
dc.identifier.scopusid | 2-s2.0-84947441015 | - |
dc.citation.endPage | 111 | - |
dc.citation.startPage | 101 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Joo, Jae Yeon | - |
dc.contributor.affiliatedAuthor | Park, Gilyong | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | biocompatibility | - |
dc.subject.keywordAuthor | anti-cancer drug | - |
dc.subject.keywordAuthor | micro-structure | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | bio-conjugation | - |
dc.subject.keywordAuthor | tumor targeting | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | PEPTIDE-BOND | - |
dc.subject.keywordPlus | PLATELET | - |
dc.subject.keywordPlus | ALPHA(V)BETA(3) | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | HYDROLYSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONJUGATE | - |
dc.subject.keywordPlus | MICELLES | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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