Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nanda, Sitansu Sekhar | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Yi, Dong Kee | - |
dc.date.available | 2020-02-28T15:42:09Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11978 | - |
dc.description.abstract | In this study, a new method for detecting creatinine was developed. This novel sensor comprised of two ionic liquids, poly-lactic-co-glycolic acid (PLGA) and 1-butyl-3-methylimidazolium (BMIM) chloride, in the presence of 2',7'-dichlorofluorescein diacetate (DCFH-DA). PLGA and BMIM chloride formed a functional porous polymer structure (FPPS)-like structure. Creatinine within the FPPS rapidly hydrolyzed and released OH-, which in turn converted DCFH-DA to DCFH, developing an intense green color or green fluorescence. The conversion of DCFH to DCF+ resulted in swelling of FPPS and increased solubility. This DCF+ based sensor could detect creatinine levels with detection limit of 5 mu M and also measure the creatinine in blood. This novel method could be used in diagnostic applications for monitoring individuals with renal dysfunction. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject | AMYLOID-BETA PROTEIN | - |
dc.subject | IONIC LIQUIDS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | BIOSENSORS | - |
dc.subject | DEIMINASE | - |
dc.subject | ELECTRODE | - |
dc.subject | SENSOR | - |
dc.subject | SERUM | - |
dc.subject | HOMOCYSTEINE | - |
dc.subject | CATALYSIS | - |
dc.title | Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365122300010 | - |
dc.identifier.doi | 10.2147/IJN.S88378 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.93 - 99 | - |
dc.identifier.scopusid | 2-s2.0-84947422703 | - |
dc.citation.endPage | 99 | - |
dc.citation.startPage | 93 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Nanda, Sitansu Sekhar | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | FPPS | - |
dc.subject.keywordAuthor | creatinine | - |
dc.subject.keywordAuthor | blood | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordPlus | AMYLOID-BETA PROTEIN | - |
dc.subject.keywordPlus | IONIC LIQUIDS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BIOSENSORS | - |
dc.subject.keywordPlus | DEIMINASE | - |
dc.subject.keywordPlus | ELECTRODE | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | HOMOCYSTEINE | - |
dc.subject.keywordPlus | CATALYSIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.