A nano-scale probing system with a gold nano-dot array for measurement of a single biomolecular interaction force
- Authors
- Kim, Sung Joo; Seo, Jeong Hyun; Lee, Jin Woo; Cho, Dong-Woo; Cha, Hyung Joon; Moon, Wonkyu
- Issue Date
- Dec-2015
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v.5, no.128, pp.105727 - 105730
- Journal Title
- RSC ADVANCES
- Volume
- 5
- Number
- 128
- Start Page
- 105727
- End Page
- 105730
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11991
- DOI
- 10.1039/c5ra23186h
- ISSN
- 2046-2069
- Abstract
- A new nano-scale probing system was proposed and developed to measure and analyze the interaction force between biomolecules at the single molecular level. A probing instrument adopting the working principle of atomic force microscopy (AFM) was designed to measure a single biomolecular interaction force with a patterned gold nano-dot array and functionalized AFM probe. The constructed probing system was evaluated through measurement of the unbinding force between a protein (Vibrio cholerae toxin B subunit) and a carbohydrate (GM1 pentasaccharide) as a model single biomolecular interaction. Thus, the developed probing system might be a potential platform for the effective measurement of single biomolecular level interactions.
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