Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells
- Authors
- Noh, Hyung Jun; Yang, Hyo Hyun; Kim, Geum Soog; Lee, Seung Eun; Lee, Dae Young; Choi, Je Hun; Kim, Seung Yu; Lee, Eun Suk; Ji, Seung Heon; Kang, Ki Sung; Park, Hye-Jin; Kim, Jae-Ryong; Kim, Ki Hyun
- Issue Date
- Dec-2015
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Ergosterol peroxide; Hericium erinaceum; human dermal fibroblasts; human umbilical vein endothelial cells; senescence associated beta-galactosidase activity
- Citation
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.30, no.6, pp.934 - 940
- Journal Title
- JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Volume
- 30
- Number
- 6
- Start Page
- 934
- End Page
- 940
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11993
- DOI
- 10.3109/14756366.2014.995181
- ISSN
- 1475-6366
- Abstract
- Hericium erinaceum is an edible and medicinal mushroom widely used in Korea, Japan, and China. On the search for biologically active compounds supporting the medicinal usage, the MeOH extract of the fruiting bodies of H. erinaceum was investigated for its chemical constituents. Six compounds were isolated and identified as hericenone D (1), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (2), erinacerin B (3), hericenone E (4), hericenone F (5) and isohericerin (6) by comparing their spectroscopic data with previously reported values. The inhibitory effects on adriamycin-induced cellular senescence in human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs) of the isolates (1-6) were studied. Among the isolated compounds, ergosterol peroxide (2) reduced senescence associated beta-galactosidase (SA-beta-gal) activity increased in HUVECs treated with adriamycin. According to experimental data obtained, the active compound may inspire the development of a new pharmacologically useful substance to be used in the treatment and prevention of age-related diseases.
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Collections - 바이오나노대학 > 식품생물공학과 > 1. Journal Articles
- 한의과대학 > 한의예과 > 1. Journal Articles
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