APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE epsilon 4 on Alzheimer's Disease Risk in a Multiracial Sample
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kyu Yeong | - |
dc.contributor.author | Lee, Jang Jae | - |
dc.contributor.author | Gunasekaran, Tamil Iniyan | - |
dc.contributor.author | Kang, Sarang | - |
dc.contributor.author | Lee, Wooje | - |
dc.contributor.author | Jeong, Jangho | - |
dc.contributor.author | Lim, Ho Jae | - |
dc.contributor.author | Zhang, Xiaoling | - |
dc.contributor.author | Zhu, Congcong | - |
dc.contributor.author | Won, So-Yoon | - |
dc.contributor.author | Choi, Yu Yong | - |
dc.contributor.author | Seo, Eun Hyun | - |
dc.contributor.author | Lee, Seok Cheol | - |
dc.contributor.author | Gim, Jungsoo | - |
dc.contributor.author | Chung, Ji Yeon | - |
dc.contributor.author | Chong, Ari | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Seo, Sujin | - |
dc.contributor.author | Ko, Pan-Woo | - |
dc.contributor.author | Han, Ji-Won | - |
dc.contributor.author | McLean, Catriona | - |
dc.contributor.author | Farrell, John | - |
dc.contributor.author | Lunetta, Kathryn L. | - |
dc.contributor.author | Miyashita, Akinori | - |
dc.contributor.author | Hara, Norikazu | - |
dc.contributor.author | Won, Sungho | - |
dc.contributor.author | Choi, Seong-Min | - |
dc.contributor.author | Ha, Jung-Min | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Kuwano, Ryozo | - |
dc.contributor.author | Song, Min Kyung | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Lee, Young Min | - |
dc.contributor.author | Park, Kyung Won | - |
dc.contributor.author | Lee, Ho-Won | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Rhee, Sangmyung | - |
dc.contributor.author | Song, Woo Keun | - |
dc.contributor.author | Lee, Jung Sup | - |
dc.contributor.author | Mayeux, Richard | - |
dc.contributor.author | Haines, Jonathan L. | - |
dc.contributor.author | Pericak-Vance, Margaret A. | - |
dc.contributor.author | Choo, Il Han | - |
dc.contributor.author | Nho, Kwangsik | - |
dc.contributor.author | Kim, Ki-Woong | - |
dc.contributor.author | Lee, Dong Young | - |
dc.contributor.author | Kim, SangYun | - |
dc.contributor.author | Kim, Byeong C. | - |
dc.contributor.author | Kim, Hoowon | - |
dc.contributor.author | Jun, Gyungah R. | - |
dc.contributor.author | Schellenberg, Gerard D. | - |
dc.contributor.author | Ikeuchi, Takeshi | - |
dc.contributor.author | Farrer, Lindsay A. | - |
dc.contributor.author | Lee, Kun Ho | - |
dc.date.available | 2020-02-27T02:41:10Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1201 | - |
dc.description.abstract | Variants in the APOE gene region may explain ethnic differences in the association of Alzheimer's disease (AD) with epsilon 4. Ethnic differences in allele frequencies for three APOE region SNPs (single nucleotide polymorphisms) were identified and tested for association in 19,398 East Asians (EastA), including Koreans and Japanese, 15,836 European ancestry (EuroA) individuals, and 4985 African Americans, and with brain imaging measures of cortical atrophy in sub-samples of Koreans and EuroAs. Among epsilon 4/epsilon 4 individuals, AD risk increased substantially in a dose-dependent manner with the number of APOE promoter SNP rs405509 T alleles in EastAs (TT: OR (odds ratio) = 27.02, p = 8.80 x 10(-94); GT: OR = 15.87, p = 2.62 x 10(-9)) and EuroAs (TT: OR = 18.13, p = 2.69 x 10(-108); GT: OR = 12.63, p = 3.44 x 10(-64)), and rs405509-T homozygotes had a younger onset and more severe cortical atrophy than those with G-allele. Functional experiments using APOE promoter fragments demonstrated that TT lowered APOE expression in human brain and serum. The modifying effect of rs405509 genotype explained much of the ethnic variability in the AD/epsilon 4 association, and increasing APOE expression might lower AD risk among epsilon 4 homozygotes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.title | APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE epsilon 4 on Alzheimer's Disease Risk in a Multiracial Sample | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000483737700129 | - |
dc.identifier.doi | 10.3390/jcm8081236 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.8 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85085559736 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | APOE | - |
dc.subject.keywordAuthor | promoter polymorphism | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | ethnic variability | - |
dc.subject.keywordAuthor | brain atrophy | - |
dc.subject.keywordAuthor | genetic association | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E EPSILON-4 | - |
dc.subject.keywordPlus | CORTICAL THICKNESS | - |
dc.subject.keywordPlus | APOE-EPSILON-4 ALLELE | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | HIPPOCAMPAL VOLUMES | - |
dc.subject.keywordPlus | AFRICAN-AMERICAN | - |
dc.subject.keywordPlus | TYPE-4 ALLELE | - |
dc.subject.keywordPlus | E GENOTYPE | - |
dc.subject.keywordPlus | E GENE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.