Inhibitory effects of ginseng sapogenins on the proliferation of triple negative breast cancer MDA-MB-231 cells
- Authors
- Kwak, Jin Ho; Park, Jun Yeon; Lee, Dahae; Kwak, Jae Young; Park, Eun Hwa; Kim, Ki Hyun; Park, Hye-Jin; Kim, Hyun Young; Jang, Hyuk Jai; Ham, Jungyeob; Hwang, Gwi Seo; Yamabe, Noriko; Kang, Ki Sung
- Issue Date
- 1-Dec-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Triple-negative breast cancers; Sapogenin; Apoptosis; Caspase
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.23, pp.5409 - 5412
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 24
- Number
- 23
- Start Page
- 5409
- End Page
- 5412
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12037
- DOI
- 10.1016/j.bmcl.2014.10.041
- ISSN
- 0960-894X
- Abstract
- Because of poor prognosis, clinical treatment of triple-negative (TN) breast cancer remains the most challenging factor in cancer treatment. Extensive research into alternative cancer therapies includes studying the naturopathic effects of the medicinal herb ginseng. This study investigates the anti-neoplastic properties of ginseng sapogenins and the derivatives: (1) (20(S)-protopanaxadiol (PPD), (2) 20(S)-protopanaxatriol), (3) (20(S)-dihydroprotopanaxadiol, and (4) 20(S)-dihydroprotopanaxatriol). These compounds were found to prevent the proliferation of MDA-MB-231 human breast cancer cells. PPD was the most potent inhibitor, exhibiting an IC50 (5.87 mu M) comparable to that of the chemotherapeutic drug taxol. Furthermore, PPD induced dose-dependent cleavage of caspase-8, caspase-3, and PARP in MDA-MB-231 cells. Thus, we propose that PPD acts as anti-cancer agent by stimulating caspase-dependent apoptosis in breast cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
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Collections - 한의과대학 > 한의예과 > 1. Journal Articles
- 바이오나노대학 > 식품생물공학과 > 1. Journal Articles
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