Anemia as a useful biomarker in patients with diffuse large B-cell lymphoma treated with R-CHOP immunochemotherapy
- Authors
- Hong, Junshik; Woo, Hyun Seon; Kim, Hyunchul; Ahn, Hee Kyung; Sym, Sun Jin; Park, Jinny; Ahn, Jeong Yeal; Cho, Eun Kyung; Shin, Dong Bok; Lee, Jae Hoon
- Issue Date
- Dec-2014
- Publisher
- WILEY
- Keywords
- Anemia; biomarkers; diffuse large B-cell lymphoma; non-Hodgkin' s lymphoma; prognosis
- Citation
- CANCER SCIENCE, v.105, no.12, pp.1569 - 1575
- Journal Title
- CANCER SCIENCE
- Volume
- 105
- Number
- 12
- Start Page
- 1569
- End Page
- 1575
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12081
- DOI
- 10.1111/cas.12544
- ISSN
- 1349-7006
- Abstract
- The aim of the current study is to evaluate the prognostic value of anemia, an easily estimable parameter in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) immunochemotherapy. A total of 157 patients with newly diagnosed diffuse large B-cell lymphoma treated with 1 cycle of R-CHOP were included. Hemoglobin level without red cell transfusion within 7days of initiation of treatment was chosen as a parameter of baseline cancer-induced anemia. To investigate the clinical significance of chemotherapy-induced anemia and its recovery after completion of treatment, 87 patients in complete remission for 6months from the time of the last cycle of R-CHOP were grouped and analyzed separately. Patients with a cancer-induced anemia of hemoglobin <10g/dL showed inferior event-free and disease-free survival compared to those with hemoglobin 10g/dL. This finding was observed irrespective of the status of pre-treatment bone marrow involvement. In multivariate analysis, hemoglobin <10g/dL was found to be an international prognostic index-independent prognostic factor. Risk of relapse was significantly higher for patients who were still anemic at 6months after R-CHOP, compared to those who achieved complete recovery from chemotherapy-induced anemia within 6 months.
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