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A novel and efficient amidation of 2-aminothiazole
- Authors
- Choi, Minho; Won, Sun-Woo; Jo, Hyeju; Viji, Mayavan; Seo, Seung-Yong; Lee, Yeon-Ju; Lee, Hyi-Seung; Lee, Heesoon; Hong, Jin Tae; Kwak, Young-Shin; Jung, Jae-Kyung
- Issue Date
- 26-Nov-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Amide; 2-Aminothiazole; Carboxamide; Transamidation; t-Butylmagnesium chloride
- Citation
- TETRAHEDRON LETTERS, v.55, no.48, pp.6582 - 6584
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 55
- Number
- 48
- Start Page
- 6582
- End Page
- 6584
- ISSN
- 0040-4039
- Abstract
- A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Seo, Seung Yong
- Pharmacy (Dept.of Pharmacy)