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Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla
- Authors
- Kim, Chung Sub; Shin, Bora; Kwon, Oh Wook; Kim, Sun Yeou; Choi, Sang Un; Oh, Dong-Chan; Kim, Ki Hyun; Lee, Kang Ro
- Issue Date
- 19-Nov-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Abies holophylla; Pinaceae; Abietane diterpene; Spiro compound
- Citation
- TETRAHEDRON LETTERS, v.55, no.47, pp.6504 - 6507
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 55
- Number
- 47
- Start Page
- 6504
- End Page
- 6507
- ISSN
- 0040-4039
- Abstract
- Holophyllin A (1), a novel rearranged abietane-type diterpenoid was isolated, together with a new diterpene glycoside, holophyllin B (2), from the trunk of Abies holophylla. The structures of 1 and 2 were established by extensive spectroscopic analyses and their absolute configurations were determined by ECD calculation. All the isolates were tested for their inhibitory effects on NO production in LPS-activated murine microglial cells. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)