Five New Oxylipins from Chaenomeles sinensis
- Authors
- Kim, Chung Sub; Kwon, Oh Wook; Kim, Sun Yeou; Choi, Sang Un; Kim, Ki Hyun; Lee, Kang Ro
- Issue Date
- Nov-2014
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Chaenomeles sinensis; Rosaceae; Oxylipins; NO; NGF
- Citation
- LIPIDS, v.49, no.11, pp.1151 - 1159
- Journal Title
- LIPIDS
- Volume
- 49
- Number
- 11
- Start Page
- 1151
- End Page
- 1159
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12137
- DOI
- 10.1007/s11745-014-3953-0
- ISSN
- 0024-4201
- Abstract
- In the course of our continuing search for bioactive constituents of Korean medicinal plants, we isolated five new oxylipins, chaenomic acid A-E (1-5), and six known ones (6-11) from the twigs of Chaenomeles sinensis. The structures of the new compounds (1-5) were determined by spectroscopic methods, including 1D and 2D NMR (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC, HMBC, and NOESY), olefin cross-metathesis, and LC/MS analysis. The known compounds (6-11) were identified by comparison of their spectroscopic data and specific optical rotation with the reported data. The isolated compounds (1-11) were tested for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells and for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, A498, and HCT-15).
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