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Graphene Oxide-based Direct Measurement of DNase I Activity with Single Stranded DNA
- Authors
- Gang, Jongback
- Issue Date
- 20-Sep-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Graphene oxide; Platform; Biosensor; DNase I
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.9, pp.2749 - 2752
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 35
- Number
- 9
- Start Page
- 2749
- End Page
- 2752
- ISSN
- 1229-5949
- Abstract
- Recent studies have shown that single-stranded DNA adsorbed onto graphene oxide is protected from DNase I cleavage. However, double-stranded DNA bound to gaphene oxide and could be digested by DNase I. To elucidate whether single-stranded DNA is protect from DNase I in the presence of graphene oxide, this study conducted DNase I digestion using single-stranded DNA and single-stranded DNA containing the duplex region in the presence of graphene oxide. Addition of DNase I resulted in restoration of the fluorescence emission that had been quenched when DNA was adsorbed to graphene oxide. It indicates that DNase I cleaved the adsorbed single-stranded DNA onto graphene oxide, which was sufficient for the detection of DNase I activity.
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Related Researcher
- Gang, Jong Back
- BioNano Technology (Department of Chemistry)