Highly sensitive and selective glucose sensor based on ultraviolet-treated nematic liquid crystals
- Authors
- Zhong, Shenghong; Jang, Chang-Hyun
- Issue Date
- 15-Sep-2014
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Keywords
- Biosensors; Glucose oxidase; Liquid crystals; PH-driven phenomenon; Optical response
- Citation
- BIOSENSORS & BIOELECTRONICS, v.59, pp.293 - 299
- Journal Title
- BIOSENSORS & BIOELECTRONICS
- Volume
- 59
- Start Page
- 293
- End Page
- 299
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12300
- DOI
- 10.1016/j.bios.2014.03.070
- ISSN
- 0956-5663
- Abstract
- Glucose is an extremely important biomolecule, and the ability to sense it has played a significant role in facilitating the understanding of many biological processes. Here, we report a novel glucose sensor based on ultraviolet (UV)-treated nematic liquid crystals. Submerging UV-treated 4-cyano-4'-pentylbiphenyl (5CB) in a glucose solution (while carefully adjusting its pH to 7.5 with NaOH and HCI) triggered an optical response, from dark to bright, observed with a polarized microscope. Notably, 5CB was located inside a glucose oxidase (GOx)-modified gold grid. We exploited this pH-driven phenomenon to design a new glucose sensor. This device could detect as little as 1 pM analyte, which is 3 orders of magnitude lower than the detection limit of the most sensitive glucose sensor currently available. It also exhibits high selectivity due to GOx modification. Thus, this is a promising technique for glucose detection, not only for clinical diagnostics, but also for sensing low levels of glucose in a biological environment (e.g., single cells and bacterial cultures). (C) 2014 Elsevier B.V. All rights reserved.
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