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A NEW CYCLIC TRITERPENE SAPONIN FROM PHYTEUMA JAPONICUM
- Issue Date
- 1-Aug-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Phyteuma japonicum; Triterpene Saponin; NGF
- Citation
- HETEROCYCLES, v.89, no.8, pp.1913 - 1922
- Journal Title
- HETEROCYCLES
- Volume
- 89
- Number
- 8
- Start Page
- 1913
- End Page
- 1922
- ISSN
- 0385-5414
- Abstract
- A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by 1D and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)